Solid Phase Peptide Synthesis: Expertise and Innovation

Over 40 Years of Excellence in Peptide Synthesis

At MacroGel, we pride ourselves on over four decades of unparalleled experience in Solid Phase Peptide Synthesis (SPPS). Our journey has been marked by continuous innovation, leading to the development of cutting-edge solid supports that enable the synthesis of complex peptides with superior efficiency and reliability.

Advantages of Using MacroGel-SPPS for Solid-Phase Peptide Synthesis

Solid-phase peptide synthesis (SPPS) is a widely employed technique for the efficient and high-throughput production of peptides. The choice of support resin is crucial for the success of the synthesis, impacting both the efficiency and the quality of the final peptide product. MacroGel-SPPS polymeric microspheres offer several significant advantages in this context, enhancing the overall SPPS process.

1. Superior Hydrophilic Properties

• Aqueous Compatibility: MacroGel-SPPS is designed with a hydrophilic PEG-based resin, which ensures compatibility with polar aprotic solvents commonly used in SPPS. This hydrophilicity facilitates improved solvation and interaction of reagents with the resin, leading to more efficient peptide synthesis.

2. Customizable Resin Properties

• Size and Loading Capacity: MacroGel-SPPS microspheres can be tailored in size and loading capacity to meet specific synthesis requirements. This customization allows for optimization based on the scale of synthesis, whether for small research-scale projects or large-scale industrial production.

• Flexible Functionalization: The resin is available with a range of linker technologies commonly used in peptide synthesis.

3. Enhanced Reaction Efficiency

• Porous Structure: The macroporous nature of MacroGel-SPPS microspheres promotes efficient diffusion of reagents and solvents throughout the resin. This ensures that the entire surface area of the microspheres is utilized effectively, leading to more uniform peptide synthesis and higher yields.

• Efficient Washing and Cleavage: The porosity also facilitates thorough washing and cleavage of peptides, reducing the likelihood of incomplete removal of by-products and increasing the overall efficiency of the synthesis process.  Each microsphere is effectively acting like a miniature sponge.

4. High-Quality Peptide Production

• Consistent Performance: The stability and consistency of MacroGel-SPPS resin contribute to reproducible results from one assembly to the next.

5. Scalability and Cost-Effectiveness

• Scalable Production: The customizable nature of MacroGel-SPPS allows for easy scaling from laboratory to industrial production. Whether you are producing small quantities for research or large volumes for commercial use, MacroGel-SPPS provides a flexible and efficient solution.

• Cost-Effective: By improving reaction efficiency and reducing purification requirements, MacroGel-SPPS can lower overall production costs. Its mechanical durability also reduces fragmentation and blockage of filters, often observed with other polymer supports.

6. Ease of Integration with Automated Systems

• Compatibility with Automation: MacroGel-SPPS microspheres are compatible with automated peptide synthesizers, making them suitable for high-throughput applications. This integration allows for streamlined and efficient peptide synthesis from small to industrial scale.

7. Versatility in Peptide Synthesis

• Wide Range of Peptides: MacroGel-SPPS can be used for the synthesis of a diverse array of peptides, including those with complex sequences or modifications. Its versatile properties accommodate various peptide synthesis strategies, including those requiring specialized linker chemistry or protecting groups.