An ideal 3D scaffold should feature a super-macroporous structure that facilitates the efficient migration of nutrients and waste, while also allowing for the rapid and unrestricted diffusion of cells. The scaffold's pores should be meticulously engineered to match the specific cell types and migration rates required. Typically, an effective pore size ranges from 40-200µm, with achieving precise pore sizes within this range being a key objective for tissue engineers.
At MacroGel, we have developed a ground-breaking method for creating super-macroporous polymer scaffolds for cell culture. This innovative process enables precise control over pore structure, volume, and dimensions, surpassing previous capabilities. Trabeculate is biodegradable and biocompatible with inherent antimicrobial properties.
Building on this advancement, we have introduced two novel hydrophilic biopolymers, Proliferex® and Trabeculate® for 3D cell culture and regenerative medicine. Proven in-vivo, separately for CNS repair and cartilage repair, these scaffolds offer enhanced control over both pore structure and chemical properties, allowing for the precise covalent or ionic attachment of cell-binding peptides or proteins. These innovations have been successfully validated in-vivo.